PlayOnLinux es una aplicación pensada para aprovechar mejor a su aplicación madre Wine enfocándose principalmente en ejecutar videojuegos del sistema operativo Windows. Es una herramienta pensada para la ejecución de programas de Windows en ambientes UNIX como Linux, pero un problema según su comunidad es que Wine, por sí solo, no es muy eficiente instalando videojuegos; y al final se presentan problemas de configuración, que disminuyen el rendimiento de la aplicación. PlayOnLinux se encarga de configurar a Wine para la ejecución adecuada de videojuegos, mediante el uso de scripts que modifican el comportamiento de Wine. Estos scripts pueden ser creados por los usuarios y su extensión de archivo es «.pol».
También permite ejecutar aplicaciones populares como Microsoft Office (2000 y 2003), Microsoft Money (2003 y 2004), Safari (el navegador de Apple), Trillian 3, WinRAR, Blender y Google SketchUp.
Lista de Juegos compatibles:
18 Wheels of Steel Haulin
Age Of Empires 2 : The Age of Kings
Age Of Empires 2 : The Conquerors Expansion
Age Of Empires 3
Age Of Empires 3 The Asian Dynasties
Age Of Empires 3 The WarChiefs
Age Of Wonders
Anno 1404
Anno 1602
Anno 1602 Koenigs-Edition
Assassin’s Creed
Baldurs Gate (5 CDs)
BaldursGate 2
BaldursGate 2 Throne of Bhaal
Battlefield 2
Best One Poker
Bioshock
Black & White 2
Blood Bowl
Borderlands
Breath of Fire IV
Cacodemons Barbecue Party in Hell
Caesar III
Call of Chtulhu: Dark Corners of the Earth
Call of Duty : Modern Warfare 2
Call Of Duty 2
Call of Duty 4 Modern Warfare
Civilization 3
Civilization 4
CivNet
Clive Barker’s Jericho
Colin Mcrae Rally 04
Colin Mcrae Rally 2
Colin Mcrae Rally 2005
Command And Conquer – Red Alert 3
Command And Conquer – Red Alert 3 Uprising
Command And Conquer 3 – Tiberium Wars – Kane Edition
Command And Conquer 3 – Tiberium Wars – Kane Wrath
Crayon Physics
Crayon Physics Deluxe
Croc Legend of the Gobbos
Dark Age of Camelot : Labyrinth of the Minotaur
Dark Age of Camelot : Trials of Atlantis
Dark Messiah Of Might And Magic
Dawn Of War : Dark Crusade
Dawn of War : Soulstorm
Deus Ex
Diablo II
Diablo II : Lord Of Destruction
Discworld
Drakensang
Druid Soccer
Duke Nukem 3D
Emperor
Escape from Monkey Island
Etherlords 2
F.E.A.R
F.E.A.R.2 : Project Origin
Fable : The Lost Chapters
Fallout 3
Fallout 3 – DLC
Far Cry 2
FlatOut II
Football Manager 2010
Forbidden
Full Tilt Poker
Future Pinball
Geheimakte Tunguska – German
GhostRecon
Goblins 3
Gothic 1
Gothic 2
Gothic 2 The Night Of The Raven
Gothic 3
Grand Theft Auto : San Andreas
Grand Theft Auto : Vice City
Grand Theft Auto 3
Grand Theft Auto IV
Grim Fandango
Guild Wars
Half Life 1
Halo Combat Evolved
Heroes of Might and Magic 5
Heroes of Might and Magic 5 : Hammer to Fate
Heroes of Might and Magic 5 : Tribes Of The East
Hidden and Dangerous Deluxe
Hitman 2
Hitman 3 : Contracts
IL2 : Sturmovik
Industry Giant II – Gold Edition
Jazz Jackrabbit 2
Jerusalem: The 3 Roads To The Holy Land
King’s Bounty: The Legend
Last Chaos
Legacy Of Kain : Defiance
Lemmings 2
Mafia
Mansion Poker
Mass Effect
Mass Effect 2
Max Payne
Max Payne 2 : The Fall of Max Payne
Midnight Club II
Monkey Island 2 Special Edition
Need For Speed Hot Pursuit 2
Need For Speed II
Need For Speed III: Hot Pursuit
Need For Speed Most Wanted
Need For Speed Undercover
Need For Speed Underground
Need For Speed Underground 2
Need For Speed: High Stakes Road Challenge
NeverWinter Nights 2
Paddy Power Poker
Painkiller
Painkiller : Battle Out Of Hell
Painkiller Black Edition
Pharaon
Pizza Syndicate
PKR Poker
Planescape Torment
Pluto Strikes Back
Poker Stars
Prehistorik
Prey
Prince Of Persia
Prince Of Persia – Sands of Time
Prince Of Persia – The Two Thrones
Prince Of Persia – Warrior Within
Prince Of Persia 2008
Race Driver : GRID
Ragnarok Online
Rally Championship 2000
Re-Volt
Red Faction II
Redneck Rampage
Reflexive Arcade games
Rfactor
Richard Burns Rally
RollerCoaster Tycoon 2
Runaway 1 – A Road Adventure
Runaway 2 – The Dream of the Turtle
Runaway 3 – A Twist of Fates
S.T.A.L.K.E.R. – Clear Sky
S.T.A.L.K.E.R. – Shadow Of Chernobyl
Sam and Max 201: Ice Station Santa
Sam and Max 202: Moai Better Blues
Sam and Max 203: Night of the Raving Dead
Sam and Max 204: Chariots of the Dogs
Sam and Max 205: What\’s New, Beelzebub?
Sam and Max Season 1
Secret Of Monkey Island Special Edition
Serious Sam – The First Encounter
Serious Sam – The Second Encounter
Settlers 4
Settlers 4 : Trojans and the elixir of power
Silent Hill 2
Silk Road Online
Sim City 2000
SimCity 4 Deluxe
SimCity 4
Soldat
Soldier of Fortune Platinum
Sonic Adventure DX
Spore
Star Wars – Episod 1 : Racer
Star Wars : Battlefront
Star Wars : Jedi Knight : Jedi Academy
Star Wars : Jedi Knight II : Jedi Outcast
Star Wars : Knights Of The Old Republic
Star Wars : Knights Of The Old Republic : The Sith Lords
Starcraft
StarCraft – Brood War (Digital Distribution Copy)
Starcraft : BroodWar
Starcraft II Wings of Liberty
Steam
Steam : Counter Strike Source
Steam : Half-Life 2
Steam : Half-Life 2 : Episode 1
Steam : Half-Life 2 : Episode 2
Steam : Natural Selection patch
Steam : Portal
Steam : Team Fortress 2
Steam HL1 mod : Sven Co-Op
Steam HL2 mod : Cinematic Mod
Steam HL2 mod : Pirates Vikings And Knights II
Strong Bad 101: Homestar Ruiner
Strong Bad 102: Strong Badia the Free
Stunt GP
Supaplex
Super Mario Brothers X
Supreme Commander
Swat 4
System Shock 2
The Elder Scrolls III – Bloodmoon
The Elder Scrolls III – Morrowind
The Elder Scrolls III – Tribunal
The Elder Scrolls IV – Knight of the nine
The Elder Scrolls IV – Oblivion
The Elder Scrolls IV – Shivering Isle
The Settlers II 10th Anniversary
The Sims 3
The Sims 3 High-End Loft Stuff
The Sims 3 Ambitions
The Sims 3 World Adventures
The Truth About Game Development
The Witcher
The Witcher Enhanced Edition
Theme Hospital
Theme Hospital Win
Theme Park World
Toca Race Driver 2
Toca Race Driver 3
Tomb Raider Anniversary
Tomb Raider Chronicles
Tomb Raider II
Tomb Raider II Golden Mask
Tomb Raider III Adventures of Lara Croft
Tomb Raider III The Lost Artefact
Tomb Raider Legend
Tomb Raider The Angel Of Darkness
Torchlight
Total Annihilation
Track Mania Nations For Ever
Trackmania United For ever
Trainz Railroad Simulator 2006
Trainz Railroad Simulator 2007
Trainz Railroad Simulator 2008
Tribes
Tropico 3
Tunneler
UFO : Enemy Unknown
Vantage Master Online
Warcraft
Warcraft II
Warcraft III
Warcraft III : The Frozen Throne
Warrior Kings Battles
Wolfenstein 3D
World in Conflict
World Of Goo
World Of Warcraft
World Of Warcraft : The Burning Crusade
Worms World Party
Zeus: Master of Olympus
Zoo Tycoon 2
Software Libre -Catamarca 